|Calculated MW||85659 Da|
|Purification||Purified IgG prepared by affinity chromatography|
|Immunogen||26 amino acid peptide corresponding to residues 150-176 on human GCR linked to thyroglobulin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Glucocorticoid receptor, GR, Nuclear receptor subfamily 3 group C member 1, NR3C1, GRL|
|Target/Specificity||Mouse anti-Human Glucocorticoid Receptor antibody, clone 5E4 recognizes the human glucocorticoid receptor, also known as Nuclear receptor subfamily 3 group C member 1 (NR3C1), a 777 amino acid receptor bearing 3 distinct functional domains, an N-terminal modulating domain, a DNA binding domain and a C-terminal steroid binding domain. The human glucocorticoid receptor is located either in the cytoplasm of cells, prior to ligand binding associated with certain heat shock proteins (Kinoet al.2009), or the nucleus following binding to ligand (Werbet al.1978).Mutations in the glucocorticoid receptor gene can lead to familial glucocorticoid resistance, characterized by elevated plasma cortisol levels (Malchoffet al.1993).Mouse anti-human glucocorticoid receptor antibody, clone 5E4 has been demonstrated to cross-react with the murine glucocorticoid receptor (Bergquistet al.2014)|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human Glucocorticoid Receptor Antibody, clone 5E4 is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
1. Berki, T. et al. (1998) Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody.J. Immunol. Methods 214: 19-27. 2. Kim, S.Y. et al. (2010) Effect of p16 on glucocorticoid response in a B-cell lymphoblast cell lineKorean J Pediatr 53: 753-8 3. Bergquist, M. et al. (2014) Glucocorticoid receptor function is decreased in neutrophils during endotoxic shock.J Infect. pii: S0163-4453(14)00081-4.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.
Request Quote Here