|Calculated MW||72621 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||ARHO-EMR3-CD97 (EGF1) transfectants.|
|Shelf Life||18 months from date of despatch.|
|Other Names||EGF-like module-containing mucin-like hormone receptor-like 3, EGF-like module receptor 3, EGF-like module-containing mucin-like hormone receptor-like 3 subunit alpha, EGF-like module-containing mucin-like hormone receptor-like 3 subunit beta, EMR3|
|Target/Specificity||Hamster anti-Human EMR3 antibody, clone 3D7 recognizes human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 (EMR3), which is a 56kD member of the EGF-7 transmembrane (TM7) family of adhesion receptors. EMR3 is expressed at the cell surface as a heterodimer. The molecule is predominantly expressed on granulocytes, and at lower levels on mature myeloid cells, monocytes and dendritic cells. EMR3 is absent on lymphocytes, haematopoietic stem cells and myeloid progenitors. Studies suggest that the EMR3 molecule is up-regulated during late stages of neutrophil differentiation and is a marker for terminally differentiated cells. The exact functions of EMR3 and its ligands have not yet been determined.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin|
|Storage||Store at +4℃ or -20℃.|
|Precautions||Anti-Human EMR3 Antibody, clone 3D7 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Matmati, M. et al. (2007) The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. J. Leukoc. Biol. 81: 440-448. 2. Drewniak, A. etal. (2009) Changes in gene expression of granulocytes during in vivo granulocyte colony-stimulating factor/dexamethasone mobilization for transfusion purposes. Blood. 113: 5979-98.1. Stacey, M. et al. (2001) Human epidermal growth factor (EGF) module-containg mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognises a ligand on human macrophages and activated neutrophils.J. Biol. Chem. 276: 18863-18870.
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