|Application ||IHC-F, FC|
|Calculated MW||30957 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Human B7-DC transfected L cells.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Programmed cell death 1 ligand 2, PD-1 ligand 2, PD-L2, PDCD1 ligand 2, Programmed death ligand 2, Butyrophilin B7-DC, B7-DC, CD273, PDCD1LG2, B7DC, CD273, PDCD1L2, PDL2|
|Target/Specificity||Mouse anti-Human CD273 antibody, clone MIH14 detects human CD273, also known as B7-DC and Programmed Death Ligand 2 (PD-L2). CD273 is a ~42 kDa member of the immunoglobulin receptor superfamily, and is a ligand for CD279 (PD-1). CD273 is primarily expressed on dendritic cells, and its expression can be induced on inflammatory macrophages when activated by interleukin 4 or Th2 cells.CD273 functions to inhibit T-cell proliferation by blocking cell cycle progression and cytokine production, and is particularly important in the maintenance of self tolerance.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD273 Antibody, clone MIH14 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Konishi, J. et al. (2004) B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression.Clin Cancer Res. 10 (15): 5094-100. 2. Volchenkov, R. et al. (2013) Type 1 regulatory T cells and regulatory B cells induced by tolerogenic dendritic cells.Scand J Immunol. 77 (4): 246-54.
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