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>   home   >   Products   >   Primary Antibodies   >   Anti-MHC Class II H-2I-Ab/s Antibody, clone OX-3    

Anti-MHC Class II H-2I-Ab/s Antibody, clone OX-3 (FITC)

Mouse Anti-Rat Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Rat
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names OX-3
Additional Information
Other Species M
Purification Purified IgG prepared by affinity chromatography from tissue culture supernatant
Immunogen Rat thymocyte membrane glycoproteins
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-MHC Class II H-2I-Ab/s antibody, clone OX-3 recognizes a polymorphic determinant of the rat RT1B MHC class II antigen, reacting with haplotypes u and l. The literature reports reactivity with Lewis, Wistar and AO strain rats but not BN, DA or PVG/c strains. Mouse anti-MHC Class II H-2I-Ab/s antibody, clone OX-3 is useful for distinguishing RT1B positive cells from different rat strains, e.g. for recognising cells of donor origin in bone marrow reconstituted radiation chimaeras.Mouse anti-MHC Class II H-2I-Ab/s antibody, clone OX-3 also cross reacts with mouse strains of the H-2 haplotypes b and s. Analysis of recombinant mouse strains has mapped the OX-3 determinant to the H-2I-A region. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the H-2 region. In rats, this complex is referred to as the RT1 region.This product is routinely tested in flow cytometry on Lewis rat splenocytes.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3); 1% Bovine Serum Albumin
Storage Store at +4℃ or -20℃.
PrecautionsAnti-MHC Class II H-2I-Ab/s Antibody, clone OX-3 (FITC) is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. McMaster, W. R. and Williams, A. F. (1979) Identification of Ia glycoproteins in rat thymus and purification from rat spleen.
Eur. J. Immunol. 9: 426-433. 2. McMaster, W. R. and Williams, A. F. (1979) Monoclonal antibodies to Ia antigens from rat thymus: cross reactions with mouse and human and use in purification of rat Ia glycoproteins.
Immunol. Rev. 47: 117-137. 3. Barclay, A.N. and Mayrhofer G. (1981) Bone marrow origin of Ia-positive cells in the medulla of rat thymus.
J. Exp. Med. 153: 1666-1671. 4. Barclay, A.N. (1981) The localization of populations of lymphocytes defined by monoclonal antibodies in rat lymphoid tissues.
Immunology 42: 593-600. 5. Zhang, J. et al. (1997) Expression of major histocompatibility complex molecules in rodent retina.
Immunohistochemical study. Invest. Ophthalmol. Vis. Sci. 38 (9): 1848 - 1857. 6. Hahm. K. et al. (2000) Loss of TGF - beta signaling contributes to autoimmune pancreatitis.
J. Clin. Invest. 105: 1057 - 1065.

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Cat# ABD12324
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