|Application ||IHC-P, IHC-F, FC, E|
|Calculated MW||94574 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Small cell lung carcinoma|
|Shelf Life||18 months from date of despatch.|
|Other Names||Neural cell adhesion molecule 1, N-CAM-1, NCAM-1, CD56, NCAM1, NCAM|
|Target/Specificity||Mouse anti-Human CD56 antibody, clone 123C3 recognizes human neural cell adhesion molecule (NCAM), otherwise known as CD56. The CD56 molecule is a cell surface glycoprotein which is expressed on neuroendocrine cells, natural killer cells and a subset of T cells in the peripheral blood. Three main isoforms of CD56 exist. Neurons express the largest 180kD form, while haemopoietic cells express the 140kD isoform. Mouse anti-Human CD56 antibody, clone 123C3 recognizes the 140 and 180kD isoforms of the CD56 protein. In neuronal tissues, CD56 mediates homophilic and heterophilic adhesion and is implicated in neural development. Studies suggest that CD56 is also expressed on thyroid follicular epithelium and may play a role in autoimmune disease of the thyroid. CD56 is expressed in a range of tumours including tumours of the lung, neural derived malignancies and natural killer cell lymphomas.|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD56 Antibody, clone 123C3 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Schol, D.J. et al. (1988) Monoclonal antibody 123C3, identifying small cell carcinoma phenotype in lung tumours, recognizes mainly, but not exclusively, endocrine and neuron-supporting normal tissues.Int. J. Cancer Suppl. 2: 34-40. 2. Mooi, W.J. et al. (1988) Monoclonal antibody 123C3 in lung tumour classification. Immunohistology of 358 resected lung tumours.Mol Cell Probes. 2: 31-37. 3. Moolenaar, C.E. et al. (1990) Expression of neural cell adhesion molecule-related sialoglycoprotein in small cell lung cancer and neuroblastoma cell lines H69 and CHP-212.Cancer Res. 50: 1102-1106. 4. Aloysius, M.M. et al. (2010) Mucins and CD56 as markers of tumour invasion and prognosis in periampullary cancer.Br J Surg. 97: 1269-78
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