|Application ||IHC-P, FC, IP|
|Calculated MW||88415 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant|
|Immunogen||Occular melanoma cell line V+B2.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Integrin beta-1, Fibronectin receptor subunit beta, Glycoprotein IIa, GPIIA, VLA-4 subunit beta, CD29, ITGB1, FNRB, MDF2, MSK12|
|Target/Specificity||Mouse anti-Human CD29 monoclonal antibody, clone 4B7R recognizes the human integrin beta 1 subunit, also known as CD29, a ~130 kDa (red) 115 kDa (non-red) single pass type I transmembrane glycoprotein expressed by most leucocytes and mesenchymal stem cells.Integrin receptors are involved in the regulation of a variety of important biological functions, including embryonic development, wound repair, hemostasis and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor cell growth, and metastasis. Surface expression of CD29 on human natural killer cells can be reduced by pretreatment with the glutathione-S-transferase inhibitor diethyl maleate (Horvath-Arcidiaconoet al.2003)|
|Preservative & Stabilisers||0.09% Sodium Azide|
|Storage||Store at +4℃ or at -20 ℃.|
|Precautions||Anti-Human CD29 Antibody, clone 4B7R is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
1. Marshall, J.F. et al. (1998) Comparative analysis of integrins in vitroandin vivo in uveal and cutaneous melanomas.Br J Cancer. 77 (4): 522-9. 2. Pillay, J. et al. (2010) Functional heterogeneity and differential priming of circulating neutrophils in human experimental endotoxemia.J Leukoc Biol. 88: 211-20. 3. Kim, B.S. et al. (2011) Effects of the dichloromethane fraction of dipsaci radix on the osteoblastic differentiation of human alveolar bone marrow-derived mesenchymal stem cells.Biosci Biotechnol Biochem. 75:13-9. 4. Kato, H. et al. (2012) The primacy of β1 integrin activation in the metastatic cascade.PLoS One. 7 (10): e46576. 5. Meng, J. et al. (2011) Contribution of human muscle-derived cells to skeletal muscle regeneration in dystrophic host mice.PLoS One. 6(3):e17454. 6. Horvath-Arcidiacono, J.A. et al. (2003) Human natural killer cell activity against porcine targets: modulation by control of the oxidation-reduction environment and role of adhesion molecule interactions.Cell Immunol. 222: 35-44. 7. Tan, D.W. et al. (2013) Single-cell gene expression profiling reveals functional heterogeneity of undifferentiated human epidermal cells.Development. 140 (7): 1433-44. 8. Yang, J. et al. (2015) Cordycepin protected against the TNF-a-induced inhibition of osteogenic differentiation of human adipose-derived mesenchymal stem cells.Int J Immunopathol Pharmacol. 28 (3): 296-307. 9. Gu, Q. et al.(2015)Ginkgo biloba extract promotes osteogenic differentiation of human bone marrow mesenchymal stem cells in a pathway involving Wnt/β-catenin signaling.Pharmacol Res. 97: 70-8.
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