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>   home   >   Products   >   Primary Antibodies   >   Anti Mouse MHC Class I Antibody, clone 2G5    

Anti-Mouse MHC Class I Antibody, clone 2G5

Mouse Anti-Mouse Monoclonal Antibody

  • FC - Anti-Mouse MHC Class I Antibody, clone 2G5  ABD12361
    Published customer image:Mouse anti Mouse MHC Class I antibody, clone 2G5 used for the evaluation of MHC class I expression on guinea pig lung infiltrates in a mycobacterial disease model by flow cytometry.Image caption:Evaluation of neutrophil infiltration and MHC expressions in the infected lung. The expression of MHC I, MHC II and percentage of neutrophils were monitored at different time points during the course of therapy. The bar diagram shows the mean percentage of MHC expression on gated population or neutrophil content in the lungs of drug or drug plus MIP group. Data represents the mean value of four animals in each group. * p
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Reactivity Mouse
Host Mouse
Clonality Monoclonal
Isotype IgG2b
Clone Names 2G5
Additional Information
Other Species Rat,Gp,Sh,B,Pig,H,Ha
Purification Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant
Immunogen Purified H-2Kb and H-2Db MHC-I molecules.
Shelf Life 18 months from date of despatch.
Target/Specificity Mouse anti-Mouse MHC Class I antibody, clone 2G5 recognizes a monomorphic epitope present on murine MHC class I molecules, expressed at varying levels on the majority of nucleated cells. The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region.The epitope recognised by clone 2G5 is conformation dependent and is reported to be phylogenetically conserved (Claessonet al.1994). Reactivity has been observed with some canine samples suggesting that this antibody may recognize a polymorphic epitope of canine MHC class I.
Preservative & Stabilisers 0.09% Sodium Azide
Storage Store at +4℃ or at -20 ℃.
PrecautionsAnti-Mouse MHC Class I Antibody, clone 2G5 is for research use only and not for use in diagnostic or therapeutic procedures.
Citations (0)

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1. Claesson, M.H. et al. (1994) Antibodies directed against monomorphic and evolutionary conserved self epitopes may be generated in 'knock-out' mice. Development of monoclonal antibodies directed against monomorphic MHC class I determinants.
Scand. J. Immunol. 40: 257-264. 2. Vitadello, M. et al. (2010) Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation.
Arthritis Res Ther.12: R52. 3. Huang, Y.C. et al. (2008) CD5-low expression lymphocytes in canine peripheral blood show characteristics of natural killer cells.
J Leukoc Biol. 84 (6): 1501-10. 4. Liu, C.C. et al. (2008) Transient downregulation of monocyte-derived dendritic-cell differentiation, function, and survival during tumoral progression and regression in an in vivo canine model of transmissible venereal tumor.
Cancer Immunol Immunother. 57 (4): 479-91. 5. Letellier, M. et al. (2008) Normal adult climbing fiber monoinnervation of cerebellar Purkinje cells in mice lacking MHC class I molecules.
Dev Neurobiol. 68 (8): 997-1006. 6. Gupta, A. et al. (2012) Efficacy of Mycobacterium indicus pranii immunotherapy as an adjunct to chemotherapy for tuberculosis and underlying immune responses in the lung.
PLoS One. 7 (7): e39215. 7. Giunchetti, R.C. et al. (2007) Immunogenicity of a killed Leishmania vaccine with saponin adjuvant in dogs.
Vaccine. 25 (44): 7674-86. 8. Cenci, E. et al. (2006) Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide.
J Leukoc Biol. 79 (1): 40-5. 9. Giunchetti RC et al. (2008) A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs.
Vaccine. 26 (5): 623-38. 10. Patel, G.K. et al. (2012) A humanized stromal bed is required for engraftment of isolated human primary squamous cell carcinoma cells in immunocompromised mice.
J Invest Dermatol. 132 (2): 284-90.1. Piriou-Guzylack, L. (2008) Membrane markers of the immune cells in swine: an update.
Vet Res. 39: 54.

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Cat# ABD12361
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