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Anti Human MMP-1 Antibody, clone 3B6

Mouse Anti-Human Monoclonal Antibody

  • IHC - Anti Human MMP-1 Antibody, clone 3B6  ABD12377
    Staining of paraffin embedded normal human colon with Mouse anti Human MMP-1 after citrate retrieval
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P03956
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 3B6
Calculated MW 54007 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-1.
Shelf Life 18 months from date of despatch.
Gene ID 4312
Other Names Interstitial collagenase,, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG
Target/Specificity Mouse anti Human MMP-1 antibody, clone 3B6 recognizes human matrix metalloproteinase 1 (MMP-1), also known as interstitial or fibroblast collagenase, a 469 amino acid, in the pro-peptide form, zinc-dependent endopeptidase responsible for degrading the extracellular matrix. MMPs are also involved in cell proliferation, migration, differentiation and apoptosis (Chenet al.2013). Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active (Nagaseet al.1992). MMP expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis (Murrayet al.1996).MMP-1 is one of the collagenases, capable of degrading collagens I, II and III, all main components of the interstitial stroma (Robichaudet al.2011). MMP-1 is overexpressed in invasive melanoma, colorectal and esophageal cancers (Langenskiöldet al.2013). MMP-1 has also been implicated in arthritis and may influence atherosclerotic lesion formation (Nikkariet al.1995) . Additionally, MMP-1 has been implicated in the repair processes of the heart after myocardial infarction (Yarbroughet al.2003).Mouse anti Human MMP-1 has been used successfully for the detection of MMP-1 in gastric cancer by both Western blotting and immunohistochemistry (Murrayet al.1998).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human MMP-1 Antibody, clone 3B6 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12377
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