|Application ||WB, IHC-P, E|
|Calculated MW||53977 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Ovalbumin conjugated synthetic peptide corresponding to a region within the C-terminus of human MMP-3.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Stromelysin-1, SL-1, 188.8.131.52, Matrix metalloproteinase-3, MMP-3, Transin-1, MMP3, STMY1|
|Target/Specificity||Mouse anti Human MMP-3 antibody, clone 1B4 recognizes human matrix metalloproteinase 3, also known as MMP-3, stromelysin-1 or transin-1. MMP-3 in its pro-form is a 477 amino acid ~54kDa zinc dependent endopeptidase processed to a 378 amino acid, ~45kDa peptide in the mature form containing 4 hemopexin-likerepeats.MMPs are also involved in cell proliferation, migration, differentiation and apoptosis (Janaet al.2012). Most MMP’s are synthesised as inactive zymogens and a propeptide region must be cleaved off before the enzyme becomes active. Their expression is increased dramatically in a variety of cancer types, where it indicates invasive disease and a poor prognosis (Holmberget al.2013). MMP-3 can degrade proteoglycan, fibronectin, laminin, and type IV collagen, but not interstitial type I collagen (Wilhelmet al.1993). It can activate other MMP’s and may be involved in the repair processes of the heart after myocardial infarction (Wanget al.2011).Mouse anti human MMP-3 antibody, clone 1B4 has been used successfully for the identification of MMP-3 in gastric cancer by both Western blotting and immunohistochemistry (Murrayet al.1998)|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human MMP-3 Antibody, clone 1B4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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