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Anti Human MALT1 Antibody, clone 50

Mouse Anti-Human Monoclonal Antibody

  • IHC-P - Anti Human MALT1 Antibody, clone 50  ABD12420
    Stainig of paraffin embedded human tonsil stained with Mouse anti Human MALT1
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UDY8
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names 50
Calculated MW 92272 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Recombinant protein corresponding to amino acids 701-808 located within the C-terminal of MALT1.
Shelf Life 18 months from date of despatch.
Gene ID 10892
Other Names Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 3.4.22.-, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT
Target/Specificity Mouse anti Human MALT1 antibody, clone 50 recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphoma-associated translocation and paracaspase. MALT1 is an 824 amino acid ~93kDa protein belonging to the peptidase C14B family containing a single death domain and two Ig-like CD-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yanget al.2013).MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas (Horsmanet al.1992), which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2 (Dierlammet al.1999). Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. (Zhouet al.2005)Mouse anti Human MALT1 recognizes both MALT1 and the MALT1-API2 fusion protein (Murga Penas et al.2007).
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human MALT1 Antibody, clone 50 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12420
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