|Application ||WB, IHC-P|
|Calculated MW||92272 Da|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||Recombinant protein corresponding to amino acids 701-808 located within the C-terminal of MALT1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 3.4.22.-, MALT lymphoma-associated translocation, Paracaspase, MALT1, MLT|
|Target/Specificity||Mouse anti Human MALT1 antibody, clone 50 recognizes human mucosal-associated lymphoid tissue lymphoma translocation 1 (MALT1), also known as MALT lymphoma-associated translocation and paracaspase. MALT1 is an 824 amino acid ~93kDa protein belonging to the peptidase C14B family containing a single death domain and two Ig-like CD-type domains. In normal lymphocytes, MALT1 plays an important role in antigen receptor-mediated lymphocyte activation. In T-cells, MALT1 is recruited by activated CARMA1, along with Bcl-10, to form a CARMA1-Bcl10-MALT1 (CBM) complex which is involved in the activation of NF-kappaB (Yanget al.2013).MALT1 was initially identified as a recurrent translocation t(11;18)(q21:q21) in mucosal-associated lymphomas (Horsmanet al.1992), which creates a functional fusion oncoprotein consisting of MALT1 and apoptosis inhibitor API2 (Dierlammet al.1999). Studies suggest that overexpression of MALT1, or expression of the API2-MALT1 fusion protein, leads to the uncontrolled activation of NF-kappaB which is stimulus-independent. (Zhouet al.2005)Mouse anti Human MALT1 recognizes both MALT1 and the MALT1-API2 fusion protein (Murga Penas et al.2007).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human MALT1 Antibody, clone 50 is for research use only and not for use in diagnostic or therapeutic procedures.|
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