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Mouse Anti-Human Monoclonal Antibody
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Application 
| E |
|---|---|
| Primary Accession | P41159 |
| Reactivity | Human |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Clone Names | 3G7 |
| Calculated MW | 18641 Da |
| Purification | Purified IgG prepared by affinity chromatography on Protein A from tissue culture supernatant |
|---|---|
| Immunogen | Recombinant leptin |
| Shelf Life | 18 months from date of despatch. |
| Gene ID | 3952 |
| Other Names | Leptin, Obese protein, Obesity factor, LEP, OB, OBS |
| Target/Specificity | Mouse anti Human Leptin antibody, clone 3G7 recognizes human leptin, a 16kDa hormone that plays a key role in homeostasis, in energy intake and expenditure. It is produced by fat cells and the placenta. Leptin is a well known marker for obesity; the amount of leptin in the circulation correlates with the amount of fat tissue. Lack of functional leptin and leptin receptors lead to morbid obesity. However, leptin resistance is present in almost all obese humans, meaning that obesity is not necessarily due to a decrease in leptin, but rather to a decrease in the amount of leptin that reaches and binds to the leptin receptors in the hypothalamus. Leptin has also been implicated in a number of other processes including immune function, neuroendocrine function, the adaptive response to fasting, blood pressure, bone formation, blood cell development, glucose homeostasis, fatty acid metabolism and reproductive function. |
| Preservative & Stabilisers | 0.09% Sodium Azide (NaN3) |
| Storage | Store at +4℃ or at -20℃ if preferred. |
| Precautions | Anti Human Leptin Antibody, clone 3G7 is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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Cat# ABD12473
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