|Application ||FC, IP|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Immunogen||RBL-2H3 rat basophilic leukaemia cell line.|
|Shelf Life||18 months from date of despatch.|
|Target/Specificity||Mouse anti Rat CD49d monoclonal antibody, clone MRalpha4-1 recognizes rat CD49d, otherwise known as integrin alpha 4 chain/VLA-4, a ~150 kDa single pass type-1 transmembrane glycoprotein and member of the integrin alpha chain family, which acts as a receptor for fibronectin and CD106 (VCAM-1). CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone MRalpha4-1 inhibits the in vitroandin vivo functions of CD49d (Yasudaet al.1995). Studies have shown that in rat Peyer’s patches, clone MRalpha4-1 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes (Tsuzukiet al.1996).|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Rat CD49d Antibody, clone MRalpha4-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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