Anti Human CD279 Antibody, clone 4F12
Mouse Anti-Human Monoclonal Antibody
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- CITATIONS
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- BACKGROUND
Application ![]()
| WB, E |
---|---|
Primary Accession | Q15116 |
Reactivity | Human |
Host | Mouse |
Clonality | Monoclonal |
Isotype | IgG2b |
Clone Names | 4F12 |
Calculated MW | 31647 Da |
Purification | Purified IgG prepared by affinity chromatography on Protein G |
---|---|
Immunogen | Recombinant human CD279 (amino acids 21-167) purified from Escherichia coli. |
Shelf Life | 18 months from date of despatch. |
Gene ID | 5133 |
Other Names | Programmed cell death protein 1, Protein PD-1, hPD-1, CD279, PDCD1, PD1 |
Target/Specificity | Mouse anti Human CD279, clone 4F12 recognizes human CD279, otherwise known as PD-1/PDCD1, a type I transmembrane glycoprotein and member of the Ig superfamily, which acts as a co-stimulatory molecule and negative regulator of T-cell activation (Patsoukiset al.2012).CD279 is an immunoinhibitory receptor which interacts with its ligands CD274 (PD-L1) and CD273 (PD-L2) to inhibit the activation and proliferation of T and B cells. CD279 is associated with regulating peripheral tolerance of T cells and preventing autoimmunity and autoimmune diseases, including type I diabetes and rheumatoid arthritis (Okazakiet al.2005). |
Preservative & Stabilisers | 0.09% Sodium Azide (NaN3) |
Storage | Store at +4℃ or at -20℃ if preferred. |
Precautions | Anti Human CD279 Antibody, clone 4F12 is for research use only and not for use in diagnostic or therapeutic procedures. |
Research Areas
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Cat# ABD12548
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