|Application ||WB, IF|
|Other Accession||P02548, P08551, P07196, P19527|
|Calculated MW||62072 Da|
|Immunogen||Preparation of pig intermediate filaments.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Neurofilament light polypeptide, NF-L, 68 kDa neurofilament protein, Neurofilament triplet L protein, NEFL|
|Target/Specificity||Mouse anti Pig Neurofilament L antibody, clone DA2 recognizes Neurofilament light polypeptide, also known as neurofilament L, NF-L, 68 kDa neurofilament protein or Neurofilament triplet L protein. NF-L is a 548 amino acid ~68 kDa neurofilament. NF-L is the most abundant of the three nurofilament proteins (NF-H, NF-M and NF-L). Neurofilaments are 10nm or intermediate filaments found in neurons, with especially high concentrations along the axons, where they appear to control axonal diameter.In humans defects in the NEFL gene are the cause of Charcot-Marie-Tooth disease 1F (CMT1F), a demyelinating condition of the peripheral nervous system characterized by progressive weakness and atrophy (Jordanovaet al.2003) and the related condition Charcot-Marie-Tooth disease 2E (CMT2E), characterized by loss of muscle tissue and touch sensation with axonal degeneration in the absence of myelin alteration (De Jonghe et al.2001).|
|Preservative & Stabilisers||0.065% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Pig Neurofilament L Antibody, clone DA2 is for research use only and not for use in diagnostic or therapeutic procedures.|
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