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>   home   >   Products   >   Primary Antibodies   >   Anti Mouse TIM-2 Antibody, clone RMT2-25    

Anti Mouse TIM-2 Antibody, clone RMT2-25

Rat Anti-Mouse Monoclonal Antibody

  • FC - Anti Mouse TIM-2 Antibody, clone RMT2-25  ABD12792
    TIM-2 transfected NRK cells stained with Rat anti Mouse TIM-2:FITC
  • FC - Anti Mouse TIM-2 Antibody, clone RMT2-25  ABD12792
    TIM-2 transfected NRK cells stained with Rat anti Mouse TIM-2
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, IP, Func
Primary Accession Q8R183
Reactivity Mouse
Host Rat
Clonality Monoclonal
Isotype IgG2a
Clone Names RMT2-25
Calculated MW 33504 Da
Additional Information
Purification Purified IgG prepared by affinity chromatography on Protein G
Immunogen Tim-2-Ig, consisting of amino acids 1-230 of mouse Tim-2, coupled with the Fc portion of mouse IgG2a.
Shelf Life 18 months from date of despatch.
Gene ID 171284
Other Names T-cell immunoglobulin and mucin domain-containing protein 2, TIMD-2, T-cell immunoglobulin mucin receptor 2, TIM-2, T-cell membrane protein 2, Timd2, Tim2
Target/Specificity Rat anti Mouse TIM-2 antibody, clone RMT2-25 recognizes mouse Tim-2 (T-cell immunoglobulin mucin 2), a transmembrane glycoprotein and member of the immunoglobulin superfamily, expressed by activated lymphocytes, developmentally in the 8-cell embryo and blastocyst, and preferentially up-regulated in Th2 cells and down-regulated in Th1 cells.Tim-2 acts as a negative regulator of Th2 cells, and is implicated to play a critical role in the development of atopic disease and other Th2-biased immune responses. Tim-2 also acts as a receptor for Semaphorin 4A, a transmembrane protein expressed on dendritic cells and B cells, which plays a role in the guidance of axonal migration during neuronal development, and has been shown to enhance T cell activation.Studies using Rat anti Mouse TIM-2 antibody, clone RMT2-25 in mouse, have shown that signaling by Tim-2 can influence the proliferation and antibody production of B cells, during early phase collagen-induced arthritis (Kawamoto et al. 2011).Rat anti Mouse TIM-2 antibody, clone RMT2-25 has been shown to significantly enhance the proliferation of stimulated splenic B cells in vitro(Kawamoto et al. 2011).
Preservative & Stabilisers None present
Storage Store at -20℃ only.
PrecautionsAnti Mouse TIM-2 Antibody, clone RMT2-25 is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD12792
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