|Application ||FC, E, IP|
|Calculated MW||39667 Da|
|Other Species||B,Water Buffalo|
|Purification||Purified IgG prepared by affinity chromatography on Protein G|
|Shelf Life||18 months from date of despatch.|
|Other Names||Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein, CD14, CD14|
|Target/Specificity||Mouse anti Sheep CD14 monoclonal antibody, clone VPM66 recognises ovine CD14, a GPI-anchored ~55 kDa membrane glycoprotein and monocyte/macrophage differentiation antigen, belonging to the lipopolysaccharide receptor family. Ovine CD14 is expressed by monocytes, macrophages and peripheral blood granulocytes (Hopkinset. al.1996).CD14 acts as a receptor for the potent bacterial endotoxin, lipopolysaccharide (LPS), facilitated by LPS-binding protein. The binding of LPS to CD14 results in cell activation, the release of cytokines and the inflammatory response, and has been shown to upregulate the cell surface expression of adhesion molecules.Clone VPM66 has been shown to recognise CD14 in other domestic ruminant species including Water Buffalo (Bubalus bubalis) (Vimoset. al.1996) and domestic cattle (Hopkinset. al.1996). In addition to clone VPM66, clones VPM65andVPM67 are also available.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Sheep CD14 Antibody, clone VPM66 is for research use only and not for use in diagnostic or therapeutic procedures.|
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