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Anti Human CD243 Antibody, clone JSB-1

Mouse Anti-Human Monoclonal Antibody

Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P08183
Reactivity Human
Host Mouse
Clonality Monoclonal
Isotype IgG1
Clone Names JSB-1
Calculated MW 141479 Da
Additional Information
Immunogen Multi drug resistant chinese hamster ovary cell line, CHrC5
Shelf Life 18 months from date of despatch.
Gene ID 5243
Other Names Multidrug resistance protein 1,, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1
Target/Specificity Mouse anti Human CD243 antibody, clone JSB-1 recognizes human CD243, also known as Multidrug resistance protein 1 or P-glycoprotein-1 encoded by the ABCB1 gene. CD243 is a 1280 amino acid multi-pass membrane glycoprotein consisting of two homologous subunits bearing a hydrophobic N-terminal domain, six trans-membrane domains and a C-terminal hydrophilic domain containing a nucleotide binding site. The two sub-units are joined by a 60 amino acid linker domain (Hoet al.2003). CD243 has a predicted molecular mass of 141.5 kDa and apparent MW of ~190 kDa in Western blotting of human embryonal kidney cell line transfected with the MRP1 gene (Akanet al.2005) . CD243 is widely expressed being found in liver, kidney, small intestine and brain (Koepsell 1998).CD243 plays a critical role in the development of ‘multi-drug resistance’ during chemotherapy where it appears to control rated of efflux of chemotherapeutic drugs from cells (Scheperet al.1988). CD243 also appears to play a significant role on the development of gastrointestinal disease (Hoet al>2003), including conditions such as IBD13 or Inflammatory Bowel disease 13 (Walker-Smithet al.2009,Brantet al.2003).Mouse anti Human CD243 antibody, clone JSB-1 has been shown to detect CD243 by Western blotting in C5, a colchcine resistant CHO derived cell line, lysates (Jettéet al.1993) also in BeWo cell and placental trophoblast lysates(Ushigomeet al.2000) . Mouse anti human CD243 has also been used successfully for the detection of P-glycoprotein in teleost fish using immunohistochemistry (Hemmeret al.1995).
Preservative & Stabilisers 0.09% Sodium Azide, 0.5% Bovine Serum Albumin
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD243 Antibody, clone JSB-1 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD12899
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