|Calculated MW||146808 Da|
|Immunogen||Synthetic peptide: Internal domain of human ErbB4.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Receptor tyrosine-protein kinase erbB-4, 220.127.116.11, Proto-oncogene-like protein c-ErbB-4, Tyrosine kinase-type cell surface receptor HER4, p180erbB4, ERBB4 intracellular domain, 4ICD, E4ICD, s80HER4, ERBB4, HER4|
|Target/Specificity||ABD13269 detects an epitope within the internal region of human ErbB4, a transmembrane protein which is a member of the epidermal growth factor receptor subfamily. ErbB4 is activated by a number of factors including neuregulins and betacellulin, which leads to the cleavage of a 120kD ectodomain fragment by TACE. In the cell, the remaining 80kD fragment of ErbB4 is internalised and cleaved by gamma-secretase. This fragment translocates to the nucleus and induces cell proliferation and differentiation.ErbB4 is important in embryonic development, and mutations to its gene have been associated with cancer.|
|Preservative & Stabilisers||0.1%Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human ErbB4 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.
Request Quote Here