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Anti Human CD49d (C-Terminal) Antibody

Rabbit Anti-Human Polyclonal Antibody

  • IHC-P - Anti Human CD49d (C-Terminal) Antibody  ABD13286
    Staining of formalin fixed, paraffin embedded human thymic medulla with Rabbit anti Human CD49d
  • IHC-P - Anti Human CD49d (C-Terminal) Antibody  ABD13286
    Published customer image:Rabbit anti Human CD49d antibody used for immunohistochemistry on paraffin embedded sectionsImage caption:Human BM infiltration and treatment-free survival analysis of CLL patients with discordant VLA-4 and CD38 risk. (A) Human bone marrow biopsy histology was used to determine the BM lymphoid infiltrate rate of the individual VLA-4/CD38 discordant patients (n = 15). “High”: lymphoid infiltration of human BM greater than 50%, “Low”: = 50%. (B) Kaplan-Meier analysis of treatment-free survival of CLL patients (n = 144) separated by their VLA-4 and CD38 risk (VLA-4-/CD38-, orange line, n = 83; VLA-4+/CD38+, green line, n = 30; VLA-4-/CD38+, blue line, n = 13; VLA-4+/CD38-, red line, n = 18; Logrank test for trend compared to VLA-4-CD38- control-group, p = .0004). When comparing the individual survival curves of all patient groups, all three groups with individual or combined high-risk parameters show significantly shorter treatment free-survival than patient group with VLA-4-/CD38- (VLA-4+/CD38+, p = .0042; VLA-4-/CD38+, p
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P13612
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 114900 Da
Additional Information
Immunogen Synthetic peptide: C-terminal domain of human CD49d, conjugated to KLH.
Shelf Life 18 months from date of despatch.
Gene ID 3676
Other Names Integrin alpha-4, CD49 antigen-like family member D, Integrin alpha-IV, VLA-4 subunit alpha, CD49d, ITGA4, CD49D
Target/Specificity Rabbit anti Human CD49d polyclonal antibody detects an epitope within the C-terminal region of human CD49d, also known as integrin alpha-4 or VLA-4 subunit alpha. CD49d is a ~150kDa single pass type 1 transmembrane glycoprotein with seven FG-GAP repeats, characteristic of alpha integrins, in its extracellular domain. CD49d can be proteolytically cleaved to yield framents of 80 and 70kDa (Hemleret al.1987). CD49d associates with either CD29 to form VLA-4 or with Integrin beta-7 to form The Peyer patches-specific homing receptor LPAM-1, involved in the lymphocyte migration and homing to gut-associated lymphoid tissue (Sackstein 2006) through its interaction with MadCam-1, preferentially expressed on Peyer’s patch high endothelial venules and postcapillary venules in lamina propria (Briskinet al.1997).VLA-4 is expressed on lymphocytes, monocytes, mast cells, macrophages, basophils and eosinophils, and has key roles in inflammation, cellular adhesion and cellular activation. LPAM-1 is expressed mainly on lymphocytes, and plays a key role in lymphocyte recruitment to sites of inflammation.
Preservative & Stabilisers 0.1%Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti Human CD49d (C-Terminal) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD13286
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