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>   home   >   Products   >   Primary Antibodies   >   Anti MUNC-18 (pSer515) Antibody    

Anti MUNC-18 (pSer515) Antibody

Rabbit Anti-Rat Polyclonal Antibody

  • WB - Anti MUNC-18 (pSer515) Antibody  ABD13289
    Western blot of rat cortex lysate showing phosphospecific immunolabeling of the ~65 kDa Munc-18 protein phosphorylated at Ser515
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P61765
Reactivity Rat
Host Rabbit
Clonality Polyclonal
Isotype Polyclonal IgG
Calculated MW 67569 Da
Additional Information
Immunogen Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.
Shelf Life 12 months from date of despatch.
Gene ID 25558
Other Names Syntaxin-binding protein 1, N-Sec1, Protein unc-18 homolog 1, Unc18-1, Protein unc-18 homolog A, Unc-18A, p67, rbSec1, Stxbp1, Unc18a
Target/Specificity ABD13289 recognises Munc-18 phosphorylated at serine 515, a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C.Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.
Preservative & Stabilisers 0.09% Sodium Azide (NaN3)
Storage Store at +4℃ or at -20℃ if preferred.
PrecautionsAnti MUNC-18 (pSer515) Antibody is for research use only and not for use in diagnostic or therapeutic procedures.
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Cat# ABD13289
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