|Calculated MW||141479 Da|
|Immunogen||Synthetic peptide: cytoplasmic domain of human CD243, conjugated to keyhole limpet hemocyanin.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Multidrug resistance protein 1, 220.127.116.11, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243, ABCB1, MDR1, PGY1|
|Target/Specificity||Rabbit anti Human CD243 antibody detects CD243, also known as MDR1 (multi-drug resistance protein 1) and P-glycoprotein. CD243 is a ~170 kDa membrane-associated protein which functions as an ATP-dependent drug efflux pump with broad substrate specificity.CD243 is highly expressed in the kidney, liver, adrenal gland and intestine, suggesting a primary role in the secretion of metabolites into bile, urine and the lumen of the intestinal tract. CD243 also prevents the accumulation of toxic compounds in critical organs such as the brain, gonads, and bone marrow, and also functions in the placenta to protect the foetus.CD243 is rapidly up-regulated by chemotherapeutic drugs and is a well established mediator of multidrug resistance.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃ or at -20℃ if preferred.|
|Precautions||Anti Human CD243 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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