|Application ||WB, IHC-P, IP|
|Calculated MW||49188 Da|
|Immunogen||A synthetic peptide corresponding to amino acid sequence from the C-terminus of human WT1.|
|Shelf Life||18 months from date of despatch.|
|Other Names||Wilms tumor protein, WT33, WT1|
|Target/Specificity||Rabbit anti Human Wilms Tumor 1 antibody recognises Wilms Tumor 1, also known asWT1 or WT33. WT1 is a 449 amino acid transcription factor that plays an important role in cellular development, in particular the development of the urogenital system, additionally WT1 functions in both the role of a tumor suppressor and in an oncogenic manner in tumor formation.Defects in the the WT1 gene result in a range of disease states including Frasier syndrome (FS) characterised by progressive nephropathy, male pseudohermaphroditism with no Wils tumor (Kohsakaet al.1999), Wilms Tumour 1 (WT1) an embryonal renal malignancy (Littleet al.1992) and Denys-Drash syndrome (DDS) and autosomal dominant nephropathy with genital abnormalities with or without Wils tumor (Bairdet al.1992)WT1 is expressed in the Kidney and a subset of haematopietic cells. Multiple isoforms of WT1 have so far been recognised. Rabbit anti Human Wilms Tumor 1 antibody is expected to recognize the canonical isoform 1 and other isoforms with a normally presented C-terminal region.|
|Preservative & Stabilisers||0.09% Sodium Azide (NaN3)|
|Storage||Store at +4℃.DO NOT FREEZE.|
|Precautions||Anti Human Wilms Tumour 1 Antibody is for research use only and not for use in diagnostic or therapeutic procedures.|
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