|Application ||WB, E|
|Calculated MW||32509 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Tumor necrosis factor ligand superfamily member 10, Apo-2 ligand, Apo-2L, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, TNFSF10, APO2L, TRAIL|
|Target/Specificity||Recombinant human CD253 is a 19.6 kDa protein comprised of 168 amino acids which correspond to the TNF-homologous region of the extracellular domain of human TRAIL/ApoL2.TNF-related apoptosis-inducing ligand (TRAIL) is expressed in many tissues including spleen, lung and prostate (Wileyet al, 1995) and is capable of inducing apoptosis in a tumour specific manner (Walczaket al, 1997). Apoptosis is initiated by the binding of the two death receptors DR4 and DR5 which initiate cell death signalling via the caspase cascade. There are however two decoy receptors DcR1 and DcR2 which competitively bind to CD253 but do not initiate apoptosis (Allen and El-Deiry, 2012).A potential use for TRAIL as an anti-tumor therapeutic agent has been identified in numerous studies, demonstrating tumoricidal activity in approximately two thirds of tumor cell lines tested (Griffithet al, 1999).Recombinant human CD253 is the immunogen used to produce Rabbit anti human CD253(AHP1215).|
|Storage||Prior to reconstitution store at +4oC. Following reconstitution store at -20oC.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this pro|
|Precautions||Recombinant Human CD253 is for research use only and not for use in diagnostic or therapeutic procedures.|
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