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>   home   >   Products   >   Primary Antibodies   >   Neuroscience   >   Recombinant Human GDNF    

Recombinant Human GDNF

     
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P39905
Reactivity Human
Calculated MW 23720 Da
Additional Information
Shelf Life 3 months from date of reconstitution.
Gene ID 2668
Other Names Glial cell line-derived neurotrophic factor, hGDNF, Astrocyte-derived trophic factor, ATF, GDNF
Target/Specificity Glial cell-derived neurotrophic factor (GDNF), is 30kDa neurotrophic factor and member of the cysteine knot superfamily of growth factors. GDNF binds GDNF alpha receptor which leads to the activation of Ret protein tyrosine kinase receptor, promoting dopamine uptake and the survival and morphological differentiation of midbrain neurons. GDNF has been shown to improve conditions such as bradykinesia, rigidity and postural instability in Parkinson’s disease mouse models. Defects in the GDNF gene may cause Hirschsprung disease and congenital central hypoventilation syndrome.
Storage Prior to reconstitution store at +4oC.After reconstitution store at -20oC.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product
PrecautionsRecombinant Human GDNF is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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References

1. Lin, L.F. et al. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.
Science. 260: 1130-1132. 2. Granholm, A. et al. (2000) Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.
J. Neurosci. 20: 3182-3190.

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Cat# ABD14371
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