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Recombinant Human NT-4

Product Information
Primary Accession P34130
Reactivity Human
Calculated MW 22427 Da
Additional Information
Shelf Life 3 months from date of reconstitution.
Gene ID 4909
Other Names Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF4, NTF5
Target/Specificity Neurotrophin-4 (NT-4) is a 28 kDa neurotrophic factor and member of the cysteine knot family of growth factors, which signals via LNGFR and trkB receptors and is involved in the control, survival and differentiation of peripheral sensory sympathetic neurons. Bronchial eosinophils, activated by NT-4, may be involved in the regulation of eosinophilic inflammation in allergic asthma. NT-4 influences airway smooth muscle intracellular Ca2+ concentration which may play a role in airway disease. Expression of NT-4 occurs in embryonic and adult tissues. The highest levels are found in the prostate with lower levels in thymus, placenta, and skeletal muscle.
Storage Prior to reconstitution store at +4oC.After reconstitution store at -20oC only. Avoid repeated freezing and thawing as this may denature the protein. This product should be stored undiluted. Should this product contain a precipitate we recommend microcent
PrecautionsRecombinant Human NT-4 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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1. Ip, N. et al. (1992) Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity.
Proc. Natl. Acad. Sci. U.S.A. 89: 3060-3064.

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Cat# ABD14372
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