|Calculated MW||22427 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Neurotrophin-4, NT-4, Neurotrophin-5, NT-5, Neutrophic factor 4, NTF4, NTF5|
|Target/Specificity||Neurotrophin-4 (NT-4) is a 28 kDa neurotrophic factor and member of the cysteine knot family of growth factors, which signals via LNGFR and trkB receptors and is involved in the control, survival and differentiation of peripheral sensory sympathetic neurons. Bronchial eosinophils, activated by NT-4, may be involved in the regulation of eosinophilic inflammation in allergic asthma. NT-4 influences airway smooth muscle intracellular Ca2+ concentration which may play a role in airway disease. Expression of NT-4 occurs in embryonic and adult tissues. The highest levels are found in the prostate with lower levels in thymus, placenta, and skeletal muscle.|
|Storage||Prior to reconstitution store at +4oC.After reconstitution store at -20oC only. Avoid repeated freezing and thawing as this may denature the protein. This product should be stored undiluted. Should this product contain a precipitate we recommend microcent|
|Precautions||Recombinant Human NT-4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Ip, N. et al. (1992) Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. U.S.A. 89: 3060-3064.
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