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Recombinant Human CD95 (soluble)

     
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Product Information
Primary Accession P25445
Reactivity Human
Calculated MW 37732 Da
Additional Information
Shelf Life 6 months from date of despatch.
Gene ID 355
Other Names Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6
Target/Specificity Recombinant soluble Human CD95 corresponds to the spliced soluble form of human CD95. CD95, also known as Fas/APO-1, is a death-domain (DD) containing type I membrane glycoprotein and member of the TNF receptor superfamily, expressed by activated T and B cells, neutrophils, monocytes and thymocytes, which binds to its ligand CD95L (FasL/CD178) to mediate apoptosis. The soluble form of CD95 (sCD95), generated by alternative splicing of CD95 mRNA, has the ability to inhibit target cell apoptosis by neutralizing CD95L. Elevated levels of sCD95 have been detected in patients with systemic lupus erythematosus (SLE), and have been associated with a poor prognosis in renal cell cancer and melanoma patients.Recombinant soluble Human CD95 (PHP192) can be used in functional studies to inhibit sCD95/CD95L mediated lysis of CD95 sensitive cells.
Storage Store at -20oC only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugatio
PrecautionsRecombinant Human CD95 (soluble) is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
Citations (0)

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References

1. Paulsen, M. and Janssen, O. (2011) Pro- and anti-apoptotic CD95 signaling in T cells.
Cell Commun Signal. 9:7.

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Cat# ABD14383
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