|Calculated MW||37732 Da|
|Shelf Life||6 months from date of despatch.|
|Other Names||Tumor necrosis factor receptor superfamily member 6, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, FASLG receptor, CD95, FAS, APT1, FAS1, TNFRSF6|
|Target/Specificity||Recombinant soluble Human CD95 corresponds to the spliced soluble form of human CD95. CD95, also known as Fas/APO-1, is a death-domain (DD) containing type I membrane glycoprotein and member of the TNF receptor superfamily, expressed by activated T and B cells, neutrophils, monocytes and thymocytes, which binds to its ligand CD95L (FasL/CD178) to mediate apoptosis. The soluble form of CD95 (sCD95), generated by alternative splicing of CD95 mRNA, has the ability to inhibit target cell apoptosis by neutralizing CD95L. Elevated levels of sCD95 have been detected in patients with systemic lupus erythematosus (SLE), and have been associated with a poor prognosis in renal cell cancer and melanoma patients.Recombinant soluble Human CD95 (PHP192) can be used in functional studies to inhibit sCD95/CD95L mediated lysis of CD95 sensitive cells.|
|Storage||Store at -20oC only.Storage in frost-free freezers is not recommended.This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugatio|
|Precautions||Recombinant Human CD95 (soluble) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Paulsen, M. and Janssen, O. (2011) Pro- and anti-apoptotic CD95 signaling in T cells.Cell Commun Signal. 9:7.
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