|Calculated MW||60329 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Thrombomodulin, TM, Fetomodulin, CD141, THBD, THRM|
|Target/Specificity||Recombinant Human CD141 antigen produced in HEK293 cells represents full length human CD141, otherwise known as Thrombomodulin, is a transmembrane glycoprotein specifically synthesized by endothelial cells, which plays a critical role in the activation/conversion of protein C into protein Ca, through the formation of a complex with the coagulation factor Thrombin. The subsequent cleavage and deactivation of the coagulation factors Va and factor VIIIa by protein Ca, acts to reduce Thrombin production and hence prevent further coagulation. Plasma levels of CD141 are increased in diabetes mellitus and SLE, and Thrombomodulin can correlate with the pathogenesis of the cardiovascular diseases thrombosis and atherosclerosis.Recombinant soluble Thrombomodulin contains 491 amino acid residues, including the extracellular domain of Thrombomodulin.|
|Storage||Prior to reconstitution store at +4oC.After reconstitution store at -20oC.Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this produc|
|Precautions||Recombinant Human CD141 is for research use only and not for use in diagnostic or therapeutic procedures.|
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