|Calculated MW||54007 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Interstitial collagenase, 126.96.36.199, Fibroblast collagenase, Matrix metalloproteinase-1, MMP-1, 22 kDa interstitial collagenase, 27 kDa interstitial collagenase, MMP1, CLG|
|Target/Specificity||Recombinant Human MMP-1 antigen produced in E. coli corresponds to human MMP-1 (matrix metalloproteinase 1) containing the entire catalytic N-terminal domain and the C-terminal domain. MMP-1 otherwise known as interstitial collagenase, is a member of a family of secreted zinc-dependent endoproteases, which play a role in the degradation of extracellular matrix (ECM) components, including both fibrillar and non-fibrillar collagens, laminin, basement membrane glycoprotein and fibronectin. MMP-1 specifically cleaves types I, II, III, VII and X collagens, and also interacts with and cleaves the secreted viral Tat protein during HIV infection, resulting in a decrease in neuronal Tat's mediated neurotoxicity. MMP-1 is overexpressed in invasive melanoma (Yeet al.2001), colorectal (Hinodaet al.2001) and oesophageal (Yamashitaet al.2001) cancers, and has been implicated in arthritis, atherosclerotic lesion formation, and in the repair processes of the heart after myocardial infarction (Creemerset al.2001).|
|Storage||Prior to reconstitution store at +4oC.After reconstitution store at -20oC.Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this produc|
|Precautions||Recombinant Human MMP-1 is for research use only and not for use in diagnostic or therapeutic procedures.|
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