|Application ||WB, E|
|Calculated MW||30931 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Interleukin-1 beta, IL-1 beta, Il1b|
|Target/Specificity||Interleukin-1 beta (IL-1 beta), is a 17.5 kDa proinflammatory, cell-associated cytokine, produced by monocytes, tissue macrophages, keratinocytes and other epithelial cells. IL-1 beta promotes the proliferation of memory T cells and cytokine production. It attenuates regulatory T cell function and enables CD4+CD25- autoreactive effectors to avoid suppression. IL-1 beta signals downstream of myc and is required for angiogenesis and invasiveness of tumour cells. IL-1 beta is directly involved in neuronal injury in neurodegenerative disorders, and stimulates mitogenic FGF-like activity, bone resorption and promotes the release of collagenase and prostaglandin from synovial cells.|
|Storage||Prior to reconstitution store at +4oC.After reconstitution store at -20oC only.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend|
|Precautions||Recombinant Mouse Interleukin-1 beta is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Allan, S. et al. (2005) Interleukin-1 and neuronal injury. Nature Reviews Immunology 5: 629-640.
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