|Application ||WB, E|
|Calculated MW||15834 Da|
|Shelf Life||3 months from date of reconstitution.|
|Other Names||Interleukin-4, IL-4, B-cell IgG differentiation factor, B-cell growth factor 1, B-cell stimulatory factor 1, BSF-1, IGG1 induction factor, Lymphocyte stimulatory factor 1, Il4, Il-4|
|Target/Specificity||Recombinant Murine interleukin-4 is an E.coli derived preparation of Interleukin-4 (IL-4), also known as B-cell stimulatory factor 1. Interleukin-4 is a pleiotropic cytokine which interacts with multiple cell lineages, including T cells, fibroblasts and haematopoietic cells, and is one of the most important factors involved in B cell IgG1 and IgE class switching. IL-4 acts as a regulator of low affinity Fc receptor for IgE (CD23) expression on both lymphocytes and monocytes.|
|Storage||Prior to reconstitution store at +4oC. Following reconstitution store at -20oC.This product should be stored undiluted.Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this pro|
|Precautions||Recombinant Mouse Interleukin-4 is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
1. Thomas, M.J. et al. (2002) CD8 T cells inhibit IgE via dendritic cell IL-12 induction that promotes Th1 T cell counter-regulation.J Immunol. 168 (1): 216-23. 2. Bénéteau, M. et al. (2012) Combination of glycolysis inhibition with chemotherapy results in an antitumor immune response.Proc Natl Acad Sci U S A. 109: 20071-6. 3. Lam, R.S. et al. (2016) Unprimed, M1 and M2 Macrophages Differentially Interact with Porphyromonas gingivalis.PLoS One. 11 (7): e0158629.
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