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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   Recombinant Mouse CD253    

Recombinant Mouse CD253

     
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Product Information
Primary Accession P50592
Reactivity Mouse
Calculated MW 33477 Da
Additional Information
Shelf Life 3 months from date of reconstitution.
Gene ID 22035
Other Names Tumor necrosis factor ligand superfamily member 10, TNF-related apoptosis-inducing ligand, Protein TRAIL, CD253, Tnfsf10, Trail
Target/Specificity CD253, otherwise known as TRAIL or Apo2L, is a member of the tumour necrosis factor superfamily, which induces apoptosis in tumour and transformed cells, but not normal cells. Activation of apoptosis by CD253 occurs through binding to the death-signalling receptors DR4 (TRAILR1) and DR5 (TRAILR2), leading to formation of the death-inducing signalling complex (DISC) and the triggering of a proteolytic caspase cascade.CD253 also plays a role in immune surveillance, acting as a mediator of monocyte, NK cell, dendritic cell and T cell anti-tumour and anti-viral cytotoxicity.
Storage Prior to reconstitution store at +4oC.After reconstitution store at -20oC.Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this produc
PrecautionsRecombinant Mouse CD253 is for research use only and not for use in diagnostic or therapeutic procedures.
Research Areas
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Cat# ABD14501
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