|Description||Rabbit IgG polyclonal antibody for Transforming acidic coiled-coil-containing protein 1(TACC1) detection. Tested with WB in Human;Mouse.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Transforming acidic coiled-coil-containing protein 1, Gastric cancer antigen Ga55, Taxin-1, TACC1, KIAA1103|
|Calculated MW||87794 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Mouse|
|Subcellular Localization||Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Midbody . Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. .|
|Tissue Specificity||Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer. Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer. .|
|Protein Name||Transforming acidic coiled-coil-containing protein 1|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human TACC1 (196-235aa MTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKP), different from the related mouse sequence by fourteen amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins.|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Likely involved in the processes that promote cell division prior to the formation of differentiated tissues.|
|Cellular Location||Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Midbody. Note=Nucleus during interphase Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis|
|Tissue Location||Isoform 1, isoform 3 and isoform 5 are ubiquitous. Isoform 2 is strongly expressed in the brain, weakly detectable in lung and colon, and overexpressed in gastric cancer Isoform 4 is not detected in normal tissues, but strong expression was found in gastric cancer tissues. Down-regulated in a subset of cases of breast cancer.|
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Transforming acidic coiled-coil-containing protein 1Â is aÂ proteinÂ that in humans is encoded by theÂ TACC1Â gene. This locus may represent a breast cancer candidate gene. It is located close to FGFR1 on a region of chromosome 8 that is amplified in some breast cancers. Three transcript variants encoding different isoforms have been found for this gene.
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