|Application ||WB, ICC|
|Reactivity||Human, Mouse, Rat|
|Description||Mouse IgG monoclonal antibody for CDK6, cyclin-dependent kinase 6 (CDK6) detection. Tested with WB, ICC in Human;mouse;rat. No cross reactivity with other proteins.|
|Reconstitution||Add 1ml of PBS buffer will yield a concentration of 100ug/ml.|
|Calculated MW||36952 MW KDa|
|Application Details||Immunocytochemistry , 1 µg/ml, Human, mouse, rat, -|
Western blot, 0.5-1 µg/ml, Human, mouse, rat
|Subcellular Localization||CDK6: Cytoplasm. Nucleus. Cell projection, ruffle.Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|Cdk6: Cytoplasm|
|Tissue Specificity||CDK6: Expressed ubiquitously. Accumulates insquamous cell carcinomas, proliferating hematopoietic progenitorcells, beta-cells of pancreatic islets of Langerhans, andneuroblastomas. Reduced levels in differentiating cells.|
|Protein Name||Cyclin-dependent kinase 6|
|Contents||Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.|
|Immunogen||Recombinant human Cdk6 protein.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|
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Provided below are standard protocols that you may find useful for product applications.
The cyclin-dependent protein kinases(CDKs) regulate major cell cycle transitions in eukaryotic cells. Cyclin-dependent kinase-6(CDK6) is the earliest inducible member of the CDK family in human T lymphocytes, involved in growth factor stimulation and cell cycle progression. Germline mutations in CDK6 do not make a significant contribution to melanoma predisposition. CDK6 gene is mapped at 7q21-q22.
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