|Description||Mouse IgG monoclonal antibody for Tryptophan Hydroxylase, tryptophan hydroxylase 1; tryptophan hydroxylase 2 (TPH1; TPH2) detection. Tested with WB in Human;rat;rabbit. No cross reactivity with other proteins.|
|Reconstitution||Add 1ml of PBS buffer will yield a concentration of 100ug/ml.|
|Other Names||Tryptophan 5-hydroxylase 2, 188.8.131.52, Neuronal tryptophan hydroxylase, Tryptophan 5-monooxygenase 2, Tph2, Ntph|
|Calculated MW||55621 MW KDa|
|Application Details||Western blot, 0.5-1 µg/ml, Human, rat, rabbit|
|Tissue Specificity||TPH1: Isoform 2 seems to be less widely expressedthan isoform 1.|
|Protein Name||Tryptophan 5-hydroxylase 1; Tryptophan 5-hydroxylase 2|
|Contents||Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.|
|Immunogen||Recombinant rabbit tryptophan hydroxylase.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|
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Provided below are standard protocols that you may find useful for product applications.
Tryptophan hydroxylase is the rate-limiting enzyme in the synthesis of serotonin(5-hydroxytryptamine, or 5HT). Tryptophan hydroxylase\atalyzes the biopterin-dependent monooxygenation of tryptophan to5-hydroxytryptophan(5HT), which is subsequently decarboxylated to form the neurotransmitter serotonin. Human tryptophan hydroxylase(TPH) is mapped to chromosome 11p15.3-p14 by in situ hybridization.
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