|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Suppressor of cytokine signaling 2(SOCS2) detection. Tested with WB in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Suppressor of cytokine signaling 2, SOCS-2, Cytokine-inducible SH2 protein 2, CIS-2, STAT-induced STAT inhibitor 2, SSI-2, SOCS2, CIS2, SSI2, STATI2|
|Calculated MW||22172 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat|
|Tissue Specificity||High expression in heart, placenta, lung, kidney and prostate.|
|Protein Name||Suppressor of cytokine signaling 2(SOCS-2)|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human SOCS2(181-198aa LPLPTRLKDYLEEYKFQV), identical to the related mouse and rat sequences.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Contains 1 SH2 domain.|
|Synonyms||CIS2, SSI2, STATI2|
|Function||SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.|
|Tissue Location||High expression in heart, placenta, lung, kidney and prostate|
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Provided below are standard protocols that you may find useful for product applications.
Suppressor of cytokine signaling 2 is a protein that in humans is encoded by the SOCS2 gene. This gene encodes a member of the STAT-induced STAT inhibitor(SSI), also known as suppressor of cytokine signalling(SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon-gamma(IFN-gamma). The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor 1 receptor(IGF1R), and thus is though to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. By cytogenetic and radiation hybrid mapping, Yandava et al.(1999) mapped the SOCS2 gene to chromosome 12q21.3-q23.
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