|Description||Rabbit IgG polyclonal antibody for Nucleoplasmin-2(NPM2) detection. Tested with WB in Human.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Nucleoplasmin-2, NPM2|
|Calculated MW||24152 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human|
|Subcellular Localization||Nucleus . Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm. .|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human NPM2(25-43aa QERRTWTFRPQLEGKQSCR).|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Core histones chaperone involved in chromatin reprogramming, specially during fertilization and early embryonic development. Probably involved in sperm DNA decondensation during fertilization.|
|Cellular Location||Nucleus. Note=Found in the oocyte nucleus before nuclear membrane breakdown, after which it is redistributed to the cytoplasm.|
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Provided below are standard protocols that you may find useful for product applications.
NPM2(Nucleophosmin/Nucleoplasmin Family Member 2), Burns et al.(2003) mapped the mouse Npm2 gene to chromosome 14. Burns et al.(2003) found that female Npm2-null mice showed defects in preimplantation embryo development, with abnormalities in oocyte and early embryonic nuclei.
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