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Anti-SOX1 Picoband Antibody

     
  • WB - Anti-SOX1 Picoband Antibody ABO12094
    Anti- SOX1 Picoband antibody, ABO12094, Western blottingAll lanes: Anti SOX1 (ABO12094) at 0.5ug/mlLane 1: Rat Brain Tissue Lysate at 50ugLane 2: NIH3T3 Whole Cell Lysate at 40ugPredicted bind size: 39KDObserved bind size: 39KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB
Primary Accession O00570
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Transcription factor SOX-1(SOX1) detection. Tested with WB in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Other Names Transcription factor SOX-1, SOX1
Calculated MW 39023 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Mouse, Rat, Human
Subcellular Localization Nucleus .
Tissue Specificity Mainly expressed in the developing central nervous system.
Protein Name Transcription factor SOX-1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of Human SOX1(215-248aa QHPGAGGAHPHAHPAHPHPHHPHAHPHNPQPMHR), identical to the related mouse sequence.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins.
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name SOX1
Function Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).
Cellular Location Nucleus.
Tissue Location Mainly expressed in the developing central nervous system EMBL; Y13436; CAA73847.1; -; Genomic_DNA EMBL; AL138691; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; CH471085; EAX09158.1; -; Genomic_DNA CCDS; CCDS9523.1; - RefSeq; NP_005977.2; NM_005986.2 UniGene; Hs.202526; - ProteinModelPortal; O00570; - SMR; O00570; - BioGrid; 112539; 2 IntAct; O00570; 1 STRING; 9606.ENSP00000330218; - iPTMnet; O00570; - PhosphoSitePlus; O00570; - BioMuta; SOX1; - jPOST; O00570; - MaxQB; O00570; - PaxDb; O00570; - PeptideAtlas; O00570; - PRIDE; O00570; - ProteomicsDB; 47981; - Ensembl; ENST00000330949; ENSP00000330218; ENSG00000182968 GeneID; 6656; - KEGG; hsa:6656; - UCSC; uc001vsb.2; human CTD; 6656; - DisGeNET; 6656; - EuPathDB; HostDB:ENSG00000182968.4; - GeneCards; SOX1; - HGNC; HGNC:11189; SOX1 MIM; 602148; gene neXtProt; NX_O00570; - OpenTargets; ENSG00000182968; - PharmGKB; PA36026; - eggNOG; ENOG410IPZ0; Eukaryota eggNOG; ENOG41102MY; LUCA GeneTree; ENSGT00940000162479; - HOGENOM; HOG000231647; - HOVERGEN; HBG105663; - InParanoid; O00570; - KO; K09267; - OMA; RYDMTAL; - OrthoDB; 1161594at2759; - PhylomeDB; O00570; - TreeFam; TF351735; - GenomeRNAi; 6656; - PRO; PR:O00570; - Proteomes; UP000005640; Chromosome 13 Bgee; ENSG00000182968; Expressed in 47 organ(s), highest expression level in forebrain Genevisible; O00570; HS GO; GO:0044798; C:nuclear transcription factor complex; IBA:GO_Central GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0003677; F:DNA binding; NAS:UniProtKB GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:UniProtKB GO; GO:0030154; P:cell differentiation; IBA:GO_Central GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl GO; GO:0007417; P:central nervous system development; IBA:GO_Central GO; GO:0006325; P:chromatin organization; NAS:UniProtKB GO; GO:0021884; P:forebrain neuron development; IEA:Ensembl GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl GO; GO:0030182; P:neuron differentiation; IBA:GO_Central GO; GO:0001764; P:neuron migration; IEA:Ensembl GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central GO; GO:0021521; P:ventral spinal cord interneuron specification; IEA:Ensembl Gene3D; 1.10.30.10; -; 1 InterPro; IPR009071; HMG_box_dom InterPro; IPR036910; HMG_box_dom_sf InterPro; IPR031268; SOX-1 InterPro; IPR022097; SOX_fam PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1 Pfam; PF00505; HMG_box; 1 Pfam; PF12336; SOXp; 1 SMART; SM00398; HMG; 1 SUPFAM; SSF47095; SSF47095; 1 PROSITE; PS50118; HMG_BOX_2; 1 1: Evidence at protein level; Activator; Complete proteome; DNA-binding; Nucleus; Reference proteome; Transcription; Transcription regulation CHAIN 1 391 Transcription factor SOX-1 /FTId=PRO_0000048712 DNA_BIND 51 119 HMG box. {ECO:0000255|PROSITE- ProRule:PRU00267} COMPBIAS 27 43 Poly-Gly COMPBIAS 145 150 Poly-Gly COMPBIAS 197 204 Poly-Ala COMPBIAS 280 288 Poly-Ala COMPBIAS 296 306 Poly-Ala COMPBIAS 357 364 Poly-Ala CONFLICT 165 165 A -> P (in Ref. 1; CAA73847) CONFLICT 180 180 G -> A (in Ref. 1; CAA73847) CONFLICT 226 227 AH -> RT (in Ref. 1; CAA73847) CONFLICT 287 290 Missing (in Ref. 1; CAA73847) SEQUENCE 391 AA; 39023 MW; DD519BA97CF5E052 CRC64; MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGAKANQDR VKRPMNAFMV WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGLPYGA AAAAAAAAGG AHQNSAVAAA AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
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Background

SOX1 (for Sex determining region Y-box 1), located in 13q34, is a transcription factor in the Sox protein family. It means that this intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. SOX1 expression is restricted to neuroectodermin the tetrapod embryo. It is expressed particularly in the ventral striatum.

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$ 240.00
Cat# ABO12094
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