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Anti-RANK Picoband Antibody

     
  • WB - Anti-RANK Picoband Antibody ABO12103
    Anti- RANK Picoband antibody, ABO12103, Western blottingAll lanes: Anti RANK (ABO12103) at 0.5ug/mlWB: HEPA Whole Cell Lysate at 40ugPredicted bind size: 66KDObserved bind size: 100KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession O35305
Host Rabbit
Reactivity Mouse
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Tumor necrosis factor receptor superfamily member 11A(TNFRSF11A) detection. Tested with WB, ELISA in Mouse.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Other Names Tumor necrosis factor receptor superfamily member 11A, Osteoclast differentiation factor receptor, ODFR, Receptor activator of NF-KB, CD265, Tnfrsf11a, Rank
Calculated MW 66621 MW KDa
Application Details Western blot, 0.1-0.5 µg/ml, Mouse , -
ELISA , 0.1-0.5 µg/ml, Mouse
Subcellular Localization Cell membrane ; Single-pass type I membrane protein .
Tissue Specificity Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney. Weakly expressed in spleen and bone marrow.
Protein Name Tumor necrosis factor receptor superfamily member 11A
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen E. coli-derived mouse RANK recombinant protein (Position: C35-S214). Mouse RANK shares 95.6% amino acid (aa) sequence identity with rat RANK.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins.
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name Tnfrsf11a
Synonyms Rank
Function Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Ubiquitous expression with high levels in trabecular bone, thymus, small intestine, lung, brain and kidney Weakly expressed in spleen and bone marrow EMBL; AF019046; AAB86810.1; -; mRNA EMBL; BC019185; AAH19185.1; -; mRNA CCDS; CCDS15207.1; - RefSeq; NP_033425.3; NM_009399.3 UniGene; Mm.6251; - PDB; 3ME2; X-ray; 2.80 A; R=26-210 PDB; 3ME4; X-ray; 2.01 A; A/B=26-210 PDB; 3QBQ; X-ray; 2.50 A; B/D=32-201 PDB; 4GIQ; X-ray; 2.70 A; R=31-198 PDB; 5BNQ; X-ray; 2.80 A; R=26-210 PDBsum; 3ME2; - PDBsum; 3ME4; - PDBsum; 3QBQ; - PDBsum; 4GIQ; - PDBsum; 5BNQ; - ProteinModelPortal; O35305; - SMR; O35305; - BioGrid; 204246; 4 DIP; DIP-48710N; - ELM; O35305; - IntAct; O35305; 11 MINT; O35305; - STRING; 10090.ENSMUSP00000027559; - iPTMnet; O35305; - PhosphoSitePlus; O35305; - MaxQB; O35305; - PaxDb; O35305; - PeptideAtlas; O35305; - PRIDE; O35305; - Ensembl; ENSMUST00000027559; ENSMUSP00000027559; ENSMUSG00000026321 GeneID; 21934; - KEGG; mmu:21934; - UCSC; uc007cgp.1; mouse CTD; 8792; - MGI; MGI:1314891; Tnfrsf11a eggNOG; ENOG410IHUN; Eukaryota eggNOG; ENOG41125ED; LUCA GeneTree; ENSGT00940000161211; - HOGENOM; HOG000154659; - HOVERGEN; HBG079274; - InParanoid; O35305; - KO; K05147; - OMA; CRRNAEC; - OrthoDB; 1038336at2759; - PhylomeDB; O35305; - TreeFam; TF331157; - Reactome; R-MMU-5668541; TNFR2 non-canonical NF-kB pathway Reactome; R-MMU-5676594; TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway ChiTaRS; Tnfrsf11a; mouse EvolutionaryTrace; O35305; - PRO; PR:O35305; - Proteomes; UP000000589; Chromosome 1 Bgee; ENSMUSG00000026321; Expressed in 112 organ(s), highest expression level in submandibular gland Genevisible; O35305; MM GO; GO:0009986; C:cell surface; IDA:MGI GO; GO:0005829; C:cytosol; ISO:MGI GO; GO:0009897; C:external side of plasma membrane; ISO:MGI GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW GO; GO:0005886; C:plasma membrane; ISO:MGI GO; GO:0019955; F:cytokine binding; ISO:MGI GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW GO; GO:0004888; F:transmembrane signaling receptor activity; ISO:MGI GO; GO:0005031; F:tumor necrosis factor-activated receptor activity; IMP:BHF-UCL GO; GO:0002250; P:adaptive immune response; ISO:MGI GO; GO:0060086; P:circadian temperature homeostasis; IMP:BHF-UCL GO; GO:0048535; P:lymph node development; IMP:MGI GO; GO:0060749; P:mammary gland alveolus development; IMP:MGI GO; GO:0007275; P:multicellular organism development; IMP:MGI GO; GO:0072674; P:multinuclear osteoclast differentiation; IMP:MGI GO; GO:0001503; P:ossification; IMP:MGI GO; GO:0030316; P:osteoclast differentiation; ISO:MGI GO; GO:0045780; P:positive regulation of bone resorption; IMP:MGI GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IMP:BHF-UCL GO; GO:0071848; P:positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling; ISO:MGI GO; GO:0071812; P:positive regulation of fever generation by positive regulation of prostaglandin secretion; IMP:BHF-UCL GO; GO:0043507; P:positive regulation of JUN kinase activity; ISO:MGI GO; GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISO:MGI GO; GO:0034097; P:response to cytokine; ISO:MGI GO; GO:0070555; P:response to interleukin-1; IMP:BHF-UCL GO; GO:0032496; P:response to lipopolysaccharide; IMP:BHF-UCL GO; GO:0009314; P:response to radiation; IEA:Ensembl GO; GO:0034612; P:response to tumor necrosis factor; IMP:BHF-UCL GO; GO:0071847; P:TNFSF11-mediated signaling pathway; ISO:MGI GO; GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IMP:BHF-UCL CDD; cd13411; TNFRSF11A; 1 InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg InterPro; IPR022323; TNFR_11 InterPro; IPR022361; TNFR_11A InterPro; IPR034040; TNFRSF11A_N Pfam; PF00020; TNFR_c6; 1 PRINTS; PR01961; TNFACTORR11 PRINTS; PR01974; TNFACTORR11A SMART; SM00208; TNFR; 4 PROSITE; PS00652; TNFR_NGFR_1; 1 PROSITE; PS50050; TNFR_NGFR_2; 1 1: Evidence at protein level; 3D-structure; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Signal; Sodium; Transmembrane; Transmembrane helix SIGNAL 1 30 CHAIN 31 625 Tumor necrosis factor receptor superfamily member 11A /FTId=PRO_0000034586 TOPO_DOM 31 214 Extracellular. TRANSMEM 215 234 Helical. TOPO_DOM 235 625 Cytoplasmic. REPEAT 35 69 TNFR-Cys 1 REPEAT 72 113 TNFR-Cys 2 REPEAT 115 152 TNFR-Cys 3 REPEAT 155 195 TNFR-Cys 4 METAL 134 134 Sodium; via carbonyl oxygen METAL 135 135 Sodium; via carbonyl oxygen METAL 138 138 Sodium; via carbonyl oxygen METAL 161 161 Sodium; via carbonyl oxygen METAL 163 163 Sodium; via carbonyl oxygen MOD_RES 571 571 Phosphoserine {ECO:0000250|UniProtKB:Q9Y6Q6} CARBOHYD 106 106 N-linked (GlcNAc...) asparagine CARBOHYD 175 175 N-linked (GlcNAc...) asparagine DISULFID 35 47 DISULFID 48 61 DISULFID 51 69 DISULFID 72 87 DISULFID 93 113 DISULFID 115 128 DISULFID 125 127 DISULFID 134 152 DISULFID 155 170 DISULFID 176 195 CONFLICT 494 494 R -> K (in Ref. 2; AAH19185) TURN 37 39 {ECO:0000244|PDB:3ME4} STRAND 40 43 {ECO:0000244|PDB:3ME4} STRAND 46 49 {ECO:0000244|PDB:3ME4} STRAND 55 59 {ECO:0000244|PDB:3ME4} STRAND 63 65 {ECO:0000244|PDB:3QBQ} STRAND 68 71 {ECO:0000244|PDB:3ME4} STRAND 80 82 {ECO:0000244|PDB:3ME4} HELIX 95 97 {ECO:0000244|PDB:3ME4} STRAND 99 103 {ECO:0000244|PDB:3ME4} STRAND 107 109 {ECO:0000244|PDB:3ME4} STRAND 112 115 {ECO:0000244|PDB:3ME4} STRAND 119 122 {ECO:0000244|PDB:3ME4} TURN 123 126 {ECO:0000244|PDB:3ME4} STRAND 127 130 {ECO:0000244|PDB:3ME4} STRAND 138 140 {ECO:0000244|PDB:3ME4} STRAND 142 145 {ECO:0000244|PDB:3ME4} STRAND 146 148 {ECO:0000244|PDB:4GIQ} STRAND 152 154 {ECO:0000244|PDB:3ME4} STRAND 165 167 {ECO:0000244|PDB:3ME4} HELIX 176 179 {ECO:0000244|PDB:3ME4} STRAND 183 185 {ECO:0000244|PDB:3ME4} STRAND 189 191 {ECO:0000244|PDB:3ME4} STRAND 194 196 {ECO:0000244|PDB:3QBQ} SEQUENCE 625 AA; 66621 MW; F8C1872E99511D8E CRC64; MAPRARRRRQ LPAPLLALCV LLVPLQVTLQ VTPPCTQERH YEHLGRCCSR CEPGKYLSSK CTPTSDSVCL PCGPDEYLDT WNEEDKCLLH KVCDAGKALV AVDPGNHTAP RRCACTAGYH WNSDCECCRR NTECAPGFGA QHPLQLNKDT VCTPCLLGFF SDVFSSTDKC KPWTNCTLLG KLEAHQGTTE SDVVCSSSMT LRRPPKEAQA YLPSLIVLLL FISVVVVAAI IFGVYYRKGG KALTANLWNW VNDACSSLSG NKESSGDRCA GSHSATSSQQ EVCEGILLMT REEKMVPEDG AGVCGPVCAA GGPWAEVRDS RTFTLVSEVE TQGDLSRKIP TEDEYTDRPS QPSTGSLLLI QQGSKSIPPF QEPLEVGEND SLSQCFTGTE STVDSEGCDF TEPPSRTDSM PVSPEKHLTK EIEGDSCLPW VVSSNSTDGY TGSGNTPGED HEPFPGSLKC GPLPQCAYSM GFPSEAAASM AEAGVRPQDR ADERGASGSG SSPSDQPPAS GNVTGNSNST FISSGQVMNF KGDIIVVYVS QTSQEGPGSA EPESEPVGRP VQEETLAHRD SFAGTAPRFP DVCATGAGLQ EQGAPRQKDG TSRPVQEQGG AQTSLHTQGS GQCAE
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Background

Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. By analysis of somatic cell and radiation hybrid panels, Anderson et al. (1997) mapped the RANK gene to 18q22.1.

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$ 240.00
Cat# ABO12103
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