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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-ABCB11 Picoband Antibody   

Anti-ABCB11 Picoband Antibody

     
  • WB - Anti-ABCB11 Picoband Antibody ABO12104
    Anti- ABCB11 Picoband antibody, ABO12104, Western blottingAll lanes: Anti ABCB11 (ABO12104) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Mouse Liver Tissue Lysate at 50ugLane 3: SMMC Whole Cell Lysate at 40ugPredicted bind size: 146KDObserved bind size: 146KD
  • IHC - Anti-ABCB11 Picoband Antibody ABO12104
    Anti- ABCB11 Picoband antibody, ABO12104, IHC(P)IHC(P): Mouse Liver Tissue
  • IHC - Anti-ABCB11 Picoband Antibody ABO12104
    Anti- ABCB11 Picoband antibody, ABO12104, IHC(P)IHC(P): Rat Liver Tissue
  • IHC - Anti-ABCB11 Picoband Antibody ABO12104
    Anti- ABCB11 Picoband antibody, ABO12104, IHC(P)IHC(P): Human Liver Cancer Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O95342
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Bile salt export pump(ABCB11) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 8647
Other Names Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCB11, BSEP
Calculated MW 146407 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat
Subcellular Localization Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.
Protein Name Bile salt export pump
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human ABCB11 (1175-1199aa KYGDNTKEIPMERVIAAAKQAQLHD), different from the related mouse and rat sequences by three amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.
Protein Information
Name ABCB11
Synonyms BSEP
Function Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ
Research Areas
Citations (0)

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Background

Bile Salt Export Pump (BSEP) is a protein which in humans is encoded by the ABCB 11 gene. It is a member of the superfamily of ATP-binding cassette (ABC) transporters, also known as ABCB11. It is mapped to chromosome 2q24. The BSEP protein is mainly expressed in the liver. ABCB11 is a gene associated with progressive familial intrahepatic cholestasis type 2 (PFIC2) which caused by mutations in the ABCB11 gene will increases the risk of hepatocellular carcinoma in early life.

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$ 280.00
Cat# ABO12104
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