|Application ||WB, IHC-P, IHC-F, ICC|
|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Annexin A3(ANXA3) detection. Tested with WB, IHC-P, IHC-F, ICC in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Annexin A3, 35-alpha calcimedin, Annexin III, Annexin-3, Inositol 1, 2-cyclic phosphate 2-phosphohydrolase, Lipocortin III, Placental anticoagulant protein III, PAP-III, ANXA3, ANX3|
|Calculated MW||36375 MW KDa|
|Application Details||Immunohistochemistry(Frozen Section), 0.5-1 µg/ml|
Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, By Heat
Western blot, 0.1-0.5 µg/ml
Immunocytochemistry , 0.5-1 µg/ml
|Protein Name||Annexin A3|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human Annexin A3 (153-184aa RKALLTLADGRRDESLKVDEHLAKQDAQILYK), different from the related mouse sequence by one amino acid, and from the related rat sequence by three amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Belongs to the annexin family.|
|Function||Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate.|
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Annexin A3 is a protein that in humans is encoded by the Annexin A3 gene. The Annexin A3 gene contains 13 exons and spans 58 kb of genomic DNA. The Annexin A3 gene is mapped to 4q21. It is abnormally expressed in fetuses of both IVF and ICSI, which may contribute to the increase risk of birth defects in these ART. This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phospholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation.
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