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Anti-EDNRB Picoband Antibody

     
  • WB - Anti-EDNRB Picoband Antibody ABO12241
    Anti- EDNRB Picoband antibody, ABO12241, Western blottingAll lanes: Anti EDNRB (ABO12241) at 0.5ug/mlWB: HELA Whole Cell Lysate at 40ugPredicted bind size: 50KDObserved bind size: 50KD
  • IHC - Anti-EDNRB Picoband Antibody ABO12241
    Anti- EDNRB Picoband antibody, ABO12241, IHC(P)IHC(P): Mouse Testis Tissue
  • IHC - Anti-EDNRB Picoband Antibody ABO12241
    Anti- EDNRB Picoband antibody, ABO12241, IHC(P)IHC(P): Rat Testis Tissue
  • IHC - Anti-EDNRB Picoband Antibody ABO12241
    Anti- EDNRB Picoband antibody, ABO12241, IHC(P)IHC(P): Human Placenta Tissue
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession P24530
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Endothelin B receptor(EDNRB) detection. Tested with WB, IHC-P in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 1910
Other Names Endothelin B receptor, ET-B, ET-BR, Endothelin receptor non-selective type, EDNRB, ETRB
Calculated MW 49644 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Mouse, Rat, By Heat
Western blot, 0.1-0.5 µg/ml, Human
Subcellular Localization Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells. .
Protein Name Endothelin B receptor
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence at the C-terminus of human EDNRB (406-439aa QSFEEKQSLEEKQSCLKFKANDHGYDNFRSSNKY), different from the related mouse and rat sequences by one amino acid.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Sequence Similarities Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.
Protein Information
Name EDNRB (HGNC:3180)
Synonyms ETRB
Function Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Cellular Location Cell membrane; Multi-pass membrane protein. Note=internalized after activation by endothelins.
Tissue Location Expressed in placental stem villi vessels, but not in cultured placental villi smooth muscle cells
Research Areas
Citations (0)

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Background

Endothelin receptor type B, also known as ETB is a protein that in humans is encoded by the EDNRB gene. The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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$ 280.00
Cat# ABO12241
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