|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Transcription factor Sp4(SP4) detection. Tested with WB in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Transcription factor Sp4, SPR-1, SP4|
|Calculated MW||81985 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat|
|Tissue Specificity||Abundant in brain.|
|Protein Name||Transcription factor Sp4|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human SP4 (592-620aa AVSPDQLTQVHLQQGQQTSDQEVQPGKRL), different from the related mouse sequence by one amino acid.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Belongs to the Sp1 C2H2-type zinc-finger protein family.|
|Function||Binds to GT and GC boxes promoters elements. Probable transcriptional activator.|
|Tissue Location||Abundant in brain.|
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Provided below are standard protocols that you may find useful for product applications.
SP4(Sp4 transcription factor), also known as Transcription factor Sp4, MGC130008, MGC130009, SPR-1, HF1B, is a protein that in humans is encoded by the SP4 gene. It is a multigene family of SP proteins. Northern blot analysis that SP4 is abundantly expressed as a 7.5-kb message in brain, but barely detectable in other human cell lines. SP4 is an activator protein like SP1. However, in contrast to SP1, SP4 is not able to act synergistically through adjacent binding sites.
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