|Description||Rabbit IgG polyclonal antibody for Fos-related antigen 2(FOSL2) detection. Tested with WB in Human;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Fos-related antigen 2, FRA-2, FOSL2, FRA2|
|Calculated MW||35193 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Rat|
|Protein Name||Fos-related antigen 2|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human FRA2 (96-127aa ALPRPGVIKTIGTTVGRRRRDEQLSPEEEEKR), identical to the related mouse and rat sequences.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Sequence Similarities||Belongs to the bZIP family. Fos subfamily.|
|Function||Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.|
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Provided below are standard protocols that you may find useful for product applications.
Fos-related antigen 2 is a protein that in humans is encoded by the FOSL2 gene. The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation.
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