|Description||Rabbit IgG polyclonal antibody for Heat shock factor protein 4(HSF4) detection. Tested with WB in Human.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Heat shock factor protein 4, HSF 4, hHSF4, Heat shock transcription factor 4, HSTF 4, HSF4|
|Calculated MW||53011 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human|
|Tissue Specificity||Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues. .|
|Protein Name||Heat shock factor protein 4|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the N-terminus of human HSF4 (149-185aa VQESTEARLRELRQQNEILWREVVTLRQSHGQQHRVI), different from the related mouse sequence by two amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.|
|Tissue Location||Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues|
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Provided below are standard protocols that you may find useful for product applications.
Heat shock factor protein 4 is a protein that in humans is encoded by the HSF4 gene. It is mapped to 16q21. Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described.
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