|Application ||WB, E|
|Description||Rabbit IgG polyclonal antibody for Bone morphogenetic protein 6(BMP6) detection. Tested with WB, ELISA in Human.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Bone morphogenetic protein 6, BMP-6, VG-1-related protein, VG-1-R, VGR-1, BMP6, VGR|
|Calculated MW||57226 MW KDa|
|Application Details||ELISA , 0.1-0.5 µg/ml, Human, -|
Western blot, 0.1-0.5 µg/ml, Human
|Subcellular Localization||Secreted .|
|Protein Name||Bone morphogenetic protein 6|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human BMP6 (383-419aa QSRNRSTQSQDVARVSSASDYNSSELKTACRKHELYV), different from the related mouse sequence by six amino acids, and from the related rat sequence by three amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Induces cartilage and bone formation.|
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Provided below are standard protocols that you may find useful for product applications.
Bone morphogenetic protein 6Â is aÂ proteinÂ that in humans is encoded by theÂ BMP6Â gene. It is mapped to 6p24-p23. The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
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