|Reactivity||Human, Mouse, Rat|
|Description||Rabbit IgG polyclonal antibody for Gap junction gamma-2 protein(GJC2) detection. Tested with WB in Human;Mouse;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Gap junction gamma-2 protein, Connexin-46.6, Cx46.6, Connexin-47, Cx47, Gap junction alpha-12 protein, GJC2, GJA12|
|Calculated MW||47002 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Mouse, Rat|
|Subcellular Localization||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.|
|Tissue Specificity||Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles. .|
|Protein Name||Gap junction gamma-2 protein|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human GJC2 (336-368aa VVRAAERARAHDQNLANLALQALRDGAAAGDRD), different from the related mouse and rat sequences by five amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a role in myelination in central and peripheral nervous systems.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell junction, gap junction|
|Tissue Location||Expressed in central nervous system, in sciatic nerve and sural nerve. Also detected in skeletal muscles|
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Provided below are standard protocols that you may find useful for product applications.
Gap junction gamma-2 (GJC2), also known as connexin-46.6 (Cx46.6) and connexin-47 (Cx47) and gap junction alpha-12 (GJA12), is a protein that in humans is encoded by the GJC2 gene. It is mapped to 1q42.13. This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans.
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