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Anti-LOX Picoband Antibody

     
  • WB - Anti-LOX Picoband Antibody ABO12404
    Anti- LOX Picoband antibody, ABO12404, Western blottingAll lanes: Anti LOX (ABO12404) at 0.5ug/mlLane 1: Rat Lung Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Thymus Tissue Lysate at 50ugLane 4: Mouse Kidney Tissue Lysate at 50ugPredicted bind size: 31KDObserved bind size: 31KD
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P28300
Host Rabbit
Reactivity Human, Mouse, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Protein-lysine 6-oxidase(LOX) detection. Tested with WB, ELISA in Human;Mouse;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 4015
Other Names Protein-lysine 6-oxidase, 1.4.3.13, Lysyl oxidase, LOX
Calculated MW 46944 MW KDa
Application Details ELISA , 0.1-0.5 µg/ml, Human, -
Western blot, 0.1-0.5 µg/ml, Mouse, Rat, Human
Subcellular Localization Secreted, extracellular space.
Tissue Specificity Heart, placenta, skeletal muscle, kidney, lung and pancreas. .
Protein Name Protein-lysine 6-oxidase
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human LOX (240-268aa AEENCLASTAYRADVRDYDHRVLLRFPQR), different from the related mouse and rat sequences by one amino acid.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name LOX
Function Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity).
Cellular Location Secreted {ECO:0000250|UniProtKB:P28301}. Secreted, extracellular space
Tissue Location Heart, placenta, skeletal muscle, kidney, lung and pancreas.
Research Areas
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Background

Lysyl oxidase (LOX), also known as protein-lysine 6-oxidase, is a protein that, in humans, is encoded by the LOX gene. The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. Defects in this gene are a cause of autosomal recessive cutis laxa type I (CL type I). Two transcript variants encoding different isoforms have been found for this gene. 

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$ 240.00
Cat# ABO12404
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