|Application ||WB, IHC-P|
|Description||Rabbit IgG polyclonal antibody for Lysyl oxidase homolog 1(LOXL1) detection. Tested with WB, IHC-P in Human.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Lysyl oxidase homolog 1, 1.4.3.-, Lysyl oxidase-like protein 1, LOL, LOXL1, LOXL|
|Calculated MW||63110 MW KDa|
|Application Details||Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, By Heat|
Western blot, 0.1-0.5 µg/ml, Human
|Subcellular Localization||Secreted, extracellular space .|
|Tissue Specificity||Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina. .|
|Protein Name||Lysyl oxidase homolog 1|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human LOXL1 (397-425aa AEEKCLASTAYAPEATDYDVRVLLRFPQR), different from the related mouse sequence by one amino acid.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Active on elastin and collagen substrates.|
|Cellular Location||Secreted, extracellular space.|
|Tissue Location||Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.|
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Lysyl oxidase homolog 1, also known asÂ LOXL1, is anÂ enzymeÂ which in humans is encoded by theÂ LOXL1Â gene. This gene encodes a member of theÂ lysyl oxidaseÂ gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks inÂ collagensÂ andÂ elastin. A highly conserved amino acid sequence at the C-terminusÂ end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. TheÂ N-terminusÂ is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, andÂ chemotaxisÂ to each member of the family.
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