|Description||Rabbit IgG polyclonal antibody for N-myc proto-oncogene protein(MYCN) detection. Tested with WB in Human;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||N-myc proto-oncogene protein, Class E basic helix-loop-helix protein 37, bHLHe37, MYCN, BHLHE37, NMYC|
|Calculated MW||49561 MW KDa|
|Application Details||Western blot, 0.1-0.5 µg/ml, Human, Rat|
|Tissue Specificity||Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level). .|
|Protein Name||N-myc proto-oncogene protein|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence at the C-terminus of human n-Myc (428-464aa EYVHSLQAEEHQLLLEKEKLQARQQQLLKKIEHARTC), different from the related mouse and rat sequences by two amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins.|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Positively regulates the transcription of MYCNOS in neuroblastoma cells.|
|Tissue Location||Expressed in the neuronal cells of the cerebrum, neuroblastomas and thyroid tumors (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
N-myc proto-oncogene protein, also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene. This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. And this protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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