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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Anti-SULT2B1 Picoband Antibody   

Anti-SULT2B1 Picoband Antibody

     
  • WB - Anti-SULT2B1 Picoband Antibody ABO12508
    Anti- SULT2B1 Picoband antibody, ABO12508, Western blottingAll lanes: Anti SULT2B1 (ABO12508) at 0.5ug/mlLane 1: Rat Testis Tissue Lysate at 50ugLane 2: A431 Whole Cell Lysate at 40ugLane 3: HELA Whole Cell Lysate at 40ugLane 4: MCF-7 Whole Cell Lysate at 40ugPredicted bind size: 48KDObserved bind size: 48KD
  • IHC - Anti-SULT2B1 Picoband Antibody ABO12508
    Anti- SULT2B1 Picoband antibody, ABO12508, IHC(P)IHC(P): Rat Intestine Tissue
  • IHC - Anti-SULT2B1 Picoband Antibody ABO12508
    Anti- SULT2B1 Picoband antibody, ABO12508, IHC(P)IHC(P): Human Intestinal Cancer Tissue
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P
Primary Accession O00204
Host Rabbit
Reactivity Human, Rat
Clonality Polyclonal
Format Lyophilized
Description Rabbit IgG polyclonal antibody for Sulfotransferase family cytosolic 2B member 1(SULT2B1) detection. Tested with WB, IHC-P in Human;Rat.
Reconstitution Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Additional Information
Gene ID 6820
Other Names Sulfotransferase family cytosolic 2B member 1, ST2B1, Sulfotransferase 2B1, 2.8.2.2, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1, HSST2
Calculated MW 41308 MW KDa
Application Details Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, By Heat

Western blot, 0.1-0.5 µg/ml, Human, Rat
Subcellular Localization Cytoplasm. Microsome. Nucleus. Phosphorylation of Ser-348 is required for translocation to the nucleus.
Tissue Specificity Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. .
Protein Name Sulfotransferase family cytosolic 2B member 1
Contents Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.
Immunogen A synthetic peptide corresponding to a sequence in the middle region of human SULT2B1 (190-218aa FDHIKGWLRMKGKDNFLFITYEELQQDLQ), different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.
Purification Immunogen affinity purified.
Cross Reactivity No cross reactivity with other proteins
Storage At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.
Protein Information
Name SULT2B1
Synonyms HSST2
Function Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).
Cellular Location Cytoplasm. Microsome. Nucleus. Cytoplasm, cytosol. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus
Tissue Location Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.
Research Areas
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Background

Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. And this gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.

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$ 280.00
Cat# ABO12508
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