|Application ||WB, IHC-P|
|Description||Rabbit IgG polyclonal antibody for Sulfotransferase family cytosolic 2B member 1(SULT2B1) detection. Tested with WB, IHC-P in Human;Rat.|
|Reconstitution||Add 0.2ml of distilled water will yield a concentration of 500ug/ml.|
|Other Names||Sulfotransferase family cytosolic 2B member 1, ST2B1, Sulfotransferase 2B1, 126.96.36.199, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1, HSST2|
|Calculated MW||41308 MW KDa|
|Application Details||Immunohistochemistry(Paraffin-embedded Section), 0.5-1 µg/ml, Human, Rat, By Heat|
Western blot, 0.1-0.5 µg/ml, Human, Rat
|Subcellular Localization||Cytoplasm. Microsome. Nucleus. Phosphorylation of Ser-348 is required for translocation to the nucleus.|
|Tissue Specificity||Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung. .|
|Protein Name||Sulfotransferase family cytosolic 2B member 1|
|Contents||Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.|
|Immunogen||A synthetic peptide corresponding to a sequence in the middle region of human SULT2B1 (190-218aa FDHIKGWLRMKGKDNFLFITYEELQQDLQ), different from the related mouse sequence by six amino acids, and from the related rat sequence by five amino acids.|
|Purification||Immunogen affinity purified.|
|Cross Reactivity||No cross reactivity with other proteins|
|Storage||At -20˚C for one year. After r˚Constitution, at 4˚C for one month. It˚Can also be aliquotted and stored frozen at -20˚C for a longer time.Avoid repeated freezing and thawing.|
|Function||Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol. Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (PubMed:28575648).|
|Cellular Location||Cytoplasm. Microsome. Nucleus. Cytoplasm, cytosol. Note=Phosphorylation of Ser-348 is required for translocation to the nucleus|
|Tissue Location||Expressed in the stratum granulosum-stratum corneum junction in the skin (at protein level). Expressed highly in placenta, prostate and trachea and lower expression in the small intestine and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Sulfotransferase family cytosolic 2B member 1 is an enzyme that in humans is encoded by the SULT2B1 gene. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. And this gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described.
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